Protein Details: Gamma-aminobutyric acid receptor subunit alpha-5

Protein ID

ICDB_Pro_0393

Protein Name

Gamma-aminobutyric acid receptor subunit alpha-5

Gene Name

Gabra5; Gabra-5

Organism

Rattus norvegicus (Rat)

Length

464 amino acids

AlphaFoldDB

AF-P19969-F1-model_v4.pdb

Function

Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA); a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels; also named GABA(A) receptors (GABAAR); consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA; GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus (By similarity). Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (By similarity).

Sequence

MDNGMLSRFIMTKTLLVFCISMTLSSHFGFSQMPTSSVQDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKERELILNKSTNAFTTGKLTHPPNIPKEQLPGGTGNAVGTASIRASEEKTSESKKTYNSISKIDKMSRIVFPILFGTFNLVYWATYLNREPVIKGATSPK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 101; /ligand="4-aminobutanoate": "ligand shared with the neighboring beta subunit GABRB3"; BINDING 164; /ligand="4-aminobutanoate": "ligand shared with the neighboring beta subunit GABRB3"

Disease

Location

Expressed in brain areas such as cerebral cortex; hippocampal formation and olfactory bulb granular layer

DOI ID

10.1016/0896-6273(89)90243-2; 10.1016/0014-5793(90)80118-3; 10.1111/j.1471-4159.1990.tb01237.x; 10.1016/0014-5793(91)81184-a; 10.1124/mol.56.3.598

RefSeq

NP_058991.1; XP_017444562.1; XP_017444563.1; XP_017444564.1; XP_017444565.1